Asuquo, 1 A. Ogunkeyede, 2 E. Bassey and 2 G. Asuquo, G.
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Asuquo, 1 A. Ogunkeyede, 2 E. Bassey and 2 G. Asuquo, G. Box , Calabar, Nigeria. E-mail: mauefas yahoo. The prevalence has increased with the emergence of HIV infection. The objective of this report is to describe the frequency, current clinical pattern, and anatomic distribution of KS in Calabar, south-eastern Nigeria and compare this with total malignant skin tumour.
Method: All the patients with histologic diagnosis of KS presenting to the University of Calabar Teaching Hospital from January and December were analyzed as part of the wider study of malignant skin tumorus. Diagnosis of HIV was based upon enzyme linked immunosorbent assay. Results: In our study, there were 11 patients 7 males and 4 females , with a male: female ratio of 1.
Nine patients Successful prevention and treatment of HIV infection would reduce the prevalence of this tumour. Kaposi sarcoma is now the most frequently reported malignant skin tumour in some areas of Africa and was endemic in Africa even before the advent of the human immunodeficiency virus HIV.
Squamous cell carcinoma SCC ranked 2nd with 10 patients All the patients were heterosexuals who presented late in hospital after prior traditional herbal treatment for periods that ranged from six months and 10 years. Single 3 Others were the face; 2 The two patients Four patients Out of these two were still being observed in the outpatient with regression of the nodules.
Follow-up has been for 6 and 8months. Two patients with localized lesions, eyelid and chronic toe ulcer with deformity had excision and amputation respectively. There was one hospital mortality in a male HIV positive patient. The fungating lesions were dressed with honey and antibiotics administered based on sensitivity, the common isolates were Staphylococcus aureus pseudomonas and proteus. Metastatic skin cancer. Table 2. We report an increased prevalence of KS in our region. The cases of KS documented by histology do not represent all the cases of KS seen as most patients with clinical suspicion did not have histopathologic diagnosis.
However, this was at variance with an earlier publication from this center which suggested that KS was not related to HIV infection.
Kaposi sarcoma was predominantly a disease of men in both the black and white. It is noteworthy that with the advent of HIV infection more females were involved contrary to previous studies with mainly endemic KS as the clinical type that involved mainly men, Wabinga et al reported in endemic KS a M: F ratio of 1.
HIV related KS has been known to affect younger patients than the other clinical types. Ignorance, poverty and socio-cultural beliefs were underlying issues as most patients presented late after prior traditional medical treatment and there after some were lost to follow-up for fear of stigmatization.
In conclusion, this study demonstrated the changing trend of KS in our region. KS is more likely to be seen in women with HIV positivity. Successful prevention and treatment of HIV infection would result in a decline in the prevalence of this tumour with improved outcome.
L'HHV-8 est un virus de la famille des herpesviridae, de la sous-famille des Gammaherpesvirinae et du genre Rhadinovirus. L'HHV-8 n'est pas un virus ubiquitaire. HHV-8 belongs to the herpesviridae family, to the gammaherpesvirinae subfamily, and to the rhadinovirus genus. Whereas several viral homologues exist in non human primates, HHV-8 is the only rhadinovirus known in human. HHV-8 is not an ubiquitous virus. It is mainly endemic in areas of high endemicity for classic or endemic Kaposi's sarcoma including the Mediterranean area and most of East and Central Africa. One can estimate that several hundred million people are HHV-8 infected worldwide with at least million on the African continent.
Localisation gastrique de sarcome de kaposi au cours de sida
Kaposi's sarcoma KS is a type of cancer that can form masses in the skin , lymph nodes , or other organs. Four sub-types are described: classic, endemic, immunosuppression therapy-related, and epidemic. Treatment is based on the sub-type, whether the condition is localized or widespread, and the person's immune function. KS lesions are nodules or blotches that may be red, purple, brown, or black, and are usually papular. They are typically found on the skin, but spread elsewhere is common, especially the mouth, gastrointestinal tract and respiratory tract. Growth can range from very slow to explosively fast, and is associated with significant mortality and morbidity. The lesions are painless, but become cosmetically disfiguring or interruptive to organs.