ENFERMEDAD DE GOODPASTURE PDF

This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease.

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This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease.

You may find these specialists through advocacy organizations, clinical trials, or articles published in medical journals. You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments. They may be able to refer you to someone they know through conferences or research efforts. Some specialists may be willing to consult with you or your local doctors over the phone or by email if you can't travel to them for care.

You can find more tips in our guide, How to Find a Disease Specialist. We also encourage you to explore the rest of this page to find resources that can help you find specialists. Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved. Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services.

Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Inclusion on this list is not an endorsement by GARD. These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand.

You may want to review these resources with a medical professional. Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know. National Institutes of Health.

COVID is an emerging, rapidly evolving situation. Menu Search Home Diseases Goodpasture syndrome. You can help advance rare disease research! Rapidly progressive glomerulonephritis with pulmonary hemorrhage; Anti-glomerular basement membrane antibody disease; Glomerulonephritis - pulmonary hemorrhage; Rapidly progressive glomerulonephritis with pulmonary hemorrhage; Anti-glomerular basement membrane antibody disease; Glomerulonephritis - pulmonary hemorrhage; Pulmonary renal syndrome See More.

Summary Summary. Symptoms Symptoms. Showing of 23 View All. Low number of red blood cells or hemoglobin. Autoimmune disease. Autoimmune disorder. Coughing up blood. Delayed loss of baby teeth. Failure to lose baby teeth. Retained baby teeth. High urine protein levels. Protein in urine. Lung infiltrates. Respiratory impairment. Inflammation of blood vessel. Blood in urine. Joint pain. Joint inflammation. Muscle ache. Muscle pain. Red or purple spots on the skin. Renal failure. Renal failure in adulthood.

Detached retina. Trouble breathing. Do you have more information about symptoms of this disease? We want to hear from you. Do you have updated information on this disease? Cause Cause. There is still much to learn about the cause of Goodpasture syndrome.

In the case of Goodpasture syndrome, antibodies form against a certain type of protein called collagen. Collagen is present in many tissues in the body. In Goodpasture syndrome, collagen in the alveoli tiny air sacs in the lungs and in the glomeruli the filtering units of the kidney is attacked.

The HLA system is involved in helping our immune system know the difference between "self" and "non-self. Each person has 3 pairs of major HLA antigens. We inherit one set from each of our parents and pass one of our two sets on to each of our children.

Diagnosis Diagnosis. Some recommend doing a kidney biopsy in all cases while others suggest only doing the biopsy when the diagnosis is still in doubt. Patients in whom the diagnosis of lung hemorrhage is still unclear should have bronchoscopy. Clinical features include severe kidney malfunction in all patients and lung hemorrhage in half of them.

Treatment Treatment. The treatment of choice is plasmapheresis in conjunction with prednisone and cyclophosphamide. Stop further production of antibodies using immunosuppression with medications, namely, corticosteroids e.

In children, plasmapheresis is done together with corticosteroids and cyclophosphamide. The duration of the immunosuppressive treatment varies but is typically 6 months for corticosteroids and 3 months for cyclophosphamide. Remove offending agents that may have initiated the antibody production. After hospital discharge, patients require long-term regular visits for monitoring kidney function and for immunosuppressive therapy.

If kidney function does not return, dialysis is continued indefinitely and the patient should be referred for kidney transplantation. If the person smokes, it is recommended he or she stop. Also, if the patient is exposed to hydrocarbon in his or her occupation, he or she should consider changing jobs, as exposure to hydrocarbon has been shown to increase a person's chances of disease recurrence. Find a Specialist Find a Specialist.

Healthcare Resources To find a medical professional who specializes in genetics, you can ask your doctor for a referral or you can search for one yourself. Research Research. Although these projects may not conduct studies on humans, you may want to contact the investigators to learn more.

To search for studies, enter the disease name in the "Text Search" box. Then click "Submit Query". Patient Registry The Autoimmune Registry supports research for Goodpasture syndrome by collecting information about patients with this and other autoimmune diseases.

You can join the registry to share your information with researchers and receive updates about participating in new research studies. Learn more about registries. Organizations Organizations. Organizations Providing General Support. American Kidney Fund, Inc. Do you know of an organization? Learn More Learn More. Where to Start MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic. The National Kidney Foundation, Inc.

NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them. In-Depth Information Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.

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Goodpasture syndrome

Autor: Dr. En las exploraciones complementarias se descubre hipoxia, pO2 55,FiO2 0. Fibronoscopia sin lesiones transbronquiales. Ecocardiograma sin alteraciones. En una muestra de esputo aparecen BAAR que no se confirman posteriormente. A pesar de que hay dudas de la pertenencia de la muestra a este enfermo se hace un tratamiento antituberculoso hasta el exitus. Reticulocitos 5.

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Goodpasture syndrome GPS , also known as anti-glomerular basement membrane disease , is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure. It is treated with medications that suppress the immune system such as corticosteroids and cyclophosphamide , and with plasmapheresis , in which the antibodies are removed from the blood. The disease was first described by an American pathologist Ernest Goodpasture of Vanderbilt University in and was later named in his honor. The anti glomerular basement membrane GBM antibodies primarily attack the kidneys and lungs, although, generalized symptoms like malaise, weight loss, fatigue, fever, and chills are also common, as are joint aches and pains.

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