ENFERMEDAD CASTLEMAN PDF

Castleman disease, or angiofollicular lymph node hyperplasia, is a rare lymphoproliferative disorder of unknown etiology and pathogenesis. Its importance lies in the fact that it has been associated with human immunodeficiency virus HIV and human herpes virus 8, as well as other neoplastic diseases such as Kaposi's sarcoma, lymphomas, and POEMS syndrome polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes.. We present the case of a year-old man with no known cardiovascular risk factors who complained of dyspnea upon moderate exertion, together with a weight loss of 4 to 5 kg over a 6-month period. A chest X-ray showed no evidence of cardiomegaly or signs of pulmonary congestion. Transthoracic echocardiography revealed the presence of mild pulmonary stenosis with a peak pressure gradient of 23mmHg and, on the parasternal short-axis view, there was a marked concentric thickening of the ascending aorta, which exerted pressure on the pulmonary artery.

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Background: Castleman's disease is an atypical lymphoproliferative disorder which may be compatible with paraneoplastic manifestations of POEMS syndrome.

Clinical case: a 53 year old man with a history of type 2 diabetes, hypothyroidism and Addison's disease presented with numbness and weakness in limbs, dyspnea, skin hardening, Raynaud's phenomenon, weight loss and fatigue. A physical exam showed tachypnea, generalized cutaneous hyperpigmentation and skin hardening of extremities, muscle weakness, hypoesthesia and hyporeflexia. Laboratory showed hyperprolactinemia, low testosterone, hypothyroidism and Addison's disease.

Electrophoresis of proteins showed polyclonal hypergammaglobulinemia. Somatosensory evoked potentials reported peripheral neuropathy and severe axonal polyneuropathy by electromyography. Chest X-rays showed bilateral reticular infiltrates and mediastinal widening. An echocardiogram displayed moderate pulmonary hypertension.

Skin biopsy had no evidence of scleroderma. CT reported axillar, mediastinal and retroperitoneal nodes. The mediastinal lesion biopsy reported hyaline vascular Castleman's disease, multicentric variety. He was treated with rituximab. Conclusions: the case meet criteria for multicentric hyaline vascular Castleman's disease, POEMS variant, treated with rituximab. This site needs JavaScript to work properly.

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Send even when there aren't any new results. Optional text in email:. Save Cancel. Create a file for external citation management software Create file Cancel. Cite Favorites. Abstract in English , Spanish. Vojnosanit Pregl. PMID: Serbian. Successful treatment with bortezomib and thalidomide for POEMS syndrome associated with multicentric mixed-type Castleman's disease. Wang X, et al. Jpn J Clin Oncol. Epub Sep 2. PMID: Sahota P, et al.

J Clin Neuromuscul Dis. Apropos of 4 cases]. Delmer A, et al. Ann Med Interne Paris. PMID: Review. Hosaka S, Kondo H. Hosaka S, et al. Show more similar articles See all similar articles.

Cited by 1 article Surgical management of isolated retroperitoneal Castleman's disease: A case report. Xu J, et al. Oncol Lett. Epub Feb 2. Publication types Case Reports Actions. Humans Actions. Male Actions. Middle Aged Actions. Supplementary concepts Multi-centric Castleman's Disease Actions.

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ANUARUL STATISTIC AL ROMANIEI 2009 PDF

[Multicentric Hyaline Vascular Castleman's Disease. A POEMS Type Variant]

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MANTO KI KAHANIYA PDF

[Unicentric Castleman's Disease in Cervical Back Space Neck]

Background: Castleman's disease is an atypical lymphoproliferative disorder which may be compatible with paraneoplastic manifestations of POEMS syndrome. Clinical case: a 53 year old man with a history of type 2 diabetes, hypothyroidism and Addison's disease presented with numbness and weakness in limbs, dyspnea, skin hardening, Raynaud's phenomenon, weight loss and fatigue. A physical exam showed tachypnea, generalized cutaneous hyperpigmentation and skin hardening of extremities, muscle weakness, hypoesthesia and hyporeflexia. Laboratory showed hyperprolactinemia, low testosterone, hypothyroidism and Addison's disease. Electrophoresis of proteins showed polyclonal hypergammaglobulinemia. Somatosensory evoked potentials reported peripheral neuropathy and severe axonal polyneuropathy by electromyography.

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Castleman disease

Reguero Callejas 2 , A. Prieto Fenech 3 , I. Alvarez 4 , E. We present a 30 year old man with a left laterocervical painless mass.

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