Pashanabheda- Bergenia ligulata Wall. Latin Name- Bergenia ligulata Family- Saxifragaceae. Ashmagna- It destroys the renal stone Sailobheda- It penetrates through the stones Upalabhedaka- It destroys the flat surface of stone Shilabheda- It grows between the wedges of stones. All the synonyms explain about the urolithic action of the herb and also about the growing pattern of the herb in between the stones.

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Ethnopharmacological relevance: Bergenia ligulata is widely used plant in South Asia, mainly India and Pakistan, as a traditional medicine for treatment of urolithiasis.

Aim of the study: To rationalize the Bergenia ligulata use in kidney stones and to explain the underlying mechanisms. Materials and methods: The crude aqueous-methanolic extract of Bergenia ligulata rhizome BLR was studied using in vitro and in vivo methods. Results: BLR inhibited calcium oxalate CaC 2 O 4 crystal aggregation as well as crystal formation in the metastable solutions and exhibited antioxidant effect against 1,1-diphenylpicrylhydrazyl free radical and lipid peroxidation in the in vitro.

BLR caused diuresis in rats accompanied by a saluretic effect. In an animal model of urolithiasis, developed in male Wistar rats by adding 0. The lithogenic treatment caused polyuria, weight loss, impairment of renal function and oxidative stress, manifested as increased malondialdehyde and protein carbonyl contents, depleted reduced glutathione and decreased antioxidant enzyme activities of the kidneys, which were prevented by BLR.

Conclusions: These data indicate the antiurolithic activity in Bergenia ligulata mediated possibly through CaC 2 O 4 crystal inhibition, diuretic, hypermagneseuric and antioxidant effects and this study rationalizes its medicinal use in urolithiasis. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable.

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Gov't Actions. MeSH terms Animals Actions. Crystallization Actions. Female Actions. Male Actions. Phytotherapy Actions. Rats Actions. Rats, Wistar Actions. Rhizome Actions. Substances Antioxidants Actions. Diuretics Actions. Plant Extracts Actions. Calcium Oxalate Actions. Magnesium Actions. Full-text links [x] Elsevier Science. Copy Download.


Antiurolithic Effect of Bergenia Ligulata Rhizome: An Explanation of the Underlying Mechanisms

The phytochemical studies have shown the presence of many secondary metabolites belonging to coumarins, flavonoids, benzenoids, lactone, carbohydrate, tannins, phenols and sterols. Crude extracts and isolated compounds from B. The objective of present review is to provide the up-to-date information that is available on the botany, pharmacognosy, traditional uses, phytochemistry, pharmacopeal standards, pharmacology and toxicology of B. It covers the information collected from scientific journals, books, theses and reports via a library and electronic search Google Scholar, Web of Science and ScienceDirect and literature available from to , which will guide in proper identification and authentication of B.


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Etymologically, the name Pashanbheda means that which breaks or destroys stones. Bergenia ligulata Wall is perennial herb that grows wild in stones and rocks. This plant has been recognized for dissolving kidney stone along with various biological activities, proving its several traditional uses. Bergenia ligulata Wall is a herb mainly found in Himalayan valley.

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